Heparin and Bone Marrow–Derived Cell Therapy

Heparin and bone marrow-derived cell therapy: friend or foe?

Cell therapy has been shown to be useful in treating some patients with acute myocardial infarction, congestive heart failure, and ischemic limbs.1–7 In harvesting, storing, or injecting the bone marrow–derived mononuclear cells (BMCs), an anticoagulant, such as heparin, is often added to prevent cell clumping. In this issue of Circulation Research, Drs Stephanie Dimmeler, Andreas Zeiher, and t...

Heparin therapy in giant cell arteritis.

Heparin improves BMSC cell therapy: Anticoagulant treatment by heparin improves the safety and therapeutic effect of bone marrow-derived mesenchymal stem cell cytotherapy

Systemic infusion of bone marrow-derived mesenchymal stem cells (BMSCs) has become a promising strategy for disease treatment and tissue regeneration. Strategies to enhance the efficiency of BMSC cell therapy are crucial to promote its clinical application. Here, we aimed to improve BMSC cell therapy by inhibiting the BMSC-induced coagulation reaction. Intravenous injection of gradient BMSCs in...

Heparin and angiogenic therapy.

Collateral circulation is an alternative source of blood supply to the myocardium if this is jeopardized by failure of the original vessel to provide adequate flow. Gradual occlusion, or a high grade stenosis of the coronary arteries, is frequently associated with collateral development in patients with coronary artery disease. Although the existence of collateral circulation in such patients i...

Comparison of leeching and heparin therapy in management of acute venous congestion of limbs in rat

Acute venous congestion leads to blood stasis in the tissue and impaired blood perfusion. Using medicinal leech is an old method for reducing tissue congestion. There are numerous factors in leech saliva and hirudin that have important roles in the leeching beneficial effect. In this study, an animal study was performed to compare leech therapy with heparin therapy in the treatment of acute ven...